RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-29a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Northern Blot; qRT-PCR; Synthesis and delivery of oligonucleotide chemistries etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA mimicry blocks pulmonary fibrosis
Year
2014
Function
"Intravenous injection of synthetic RNA duplexes can increase miR-29 levels in vivo for several days. Moreover, therapeutic delivery of these miR-29 mimics during bleomycin-induced pulmonary fibrosis restores endogenous miR-29 function whereby decreasing collagen expression and blocking and reversing pulmonary fibrosis."